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Melatonin clearly plays a role in helping to regulate human circadian rhythms, likely through its effects on melatonin receptors in the suprachiasmatic nucleus of the hypothalamus.
However, data supporting the hypothesis that melatonin is effective in the treatment of human sleep disorders is scanty at best.
Using the patient-reported sleep data, sleep latency was significantly reduced compared to placebo at weeks 1, 3, and 5, without evidence of rebound insomnia or withdrawal effects following treatment discontinuation. Used to treat anxiety and major depressive disorder. Dosing times of ssris generally hinge on avoiding unwanted activation (stimulation) or sedation. - Lexapro for anxiety Lexapro - Selective serotonin reuptake inhibitor.The study concluded that there was no evidence that melatonin effectively treats secondary sleep disorders or sleep disorders accompanying sleep restriction, such as jet lag and shift work disorder.However, evidence suggests that short-term use of melatonin is safe.