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Patients and methods: A prospective database of all HIV-positive individuals managed in a specialist unit since 1986 includes 11 112 patients (71 687 person-years of follow-up). Their clinicopathological and treatment details were analysed.
Results: At anal cancer diagnosis, the mean age was 44 years (range: 28–75 years) and the median CD4 cell count was 305 mm). Forty-six (92%) responded, of whom 10 (22%) subsequently relapsed with locoregional (70%), metastatic disease (10%) or both (20%).
As with other nonacquired immunodeficiency syndrome (AIDS)-defining malignancies, the incidence of invasive anal cancer does not seem to correlate with CD4 cell count , although some recent studies have found that a low CD4 cell nadir increases the risk of anal cancer [6, 7].
In addition, the risk of anal cancer is not declining with increasing usage of highly active antiretroviral therapy (HAART) [6–8].
The Common Toxicity Criteria for adverse events version 4.0 (CTCAE v4.0) from the National Cancer Institute was used to retrospectively score the prospectively recorded early treatment-related toxicity.
HAART is defined as the use of at least three antiretrovirals in accordance with published guidelines .
The overall 5-year survival is 65% (95% confidence interval 51% to 78%).
We present the clinical features and treatment outcomes of anal cancer in 60 HIV-positive patients over a 20-year period.From a prospective database, we identified 60 HIV-seropositive patients with histologically confirmed anal cancer diagnosed between 19.Demographics, clinicopathological data, treatment regimes, CD4 cell counts and mortality data were prospectively collected.It costs £590,000 a year to keep a Maggie's Centre open, and the money you raise will help your Maggie's Centre continue to provide emotional, practical and social support to people with cancer and their family and friends.Find out more about how your money makes a difference to Maggie's.